I use a digital press. For the limited run that I print which is an average of 200 copies, litho is prohibitive in terms of cost. I like to keep the books affordable to make and to buy. The best digital presses can output very very close to litho plate printing so it's not a concern, it just means they lack the scent of ink! At every stage an image can be altered and the alteration can affect the print out put. A basic example is below in the picture. Images can be sent to a mono machine as RGB, CMYK or grey files. They can be sent as desaturated colour files. They can be sent as colour files embedded in a PDF which is then converted. Alternatively the machine can convert. The machine can 'enhance' or be not. Really there are infinite options, each with it's peculiarities.
One thing is for certain, as with litho but to a slightly greater extent, every print run will differ. Like no two cans of custom colour mixed paint will be exactly the same.
Every book is different. For what it's worth, this book by Daniel Meadows, the top right will work best!